An integrated approach to clinical understanding
Realigning disease and pathological process in a functional and translational manner requires an integrated approach. Basic scientists and clinicians need to work together, using latest generation tools to provide industry with advice on drug performance, feed scientific knowledge into early clinical trial design and to apply new principles of experimental medicine to early phases clinical trials.
The Immunophenotyping facility at the ITM provides a novel platform to address this.
Strategically placed on the fifth floor of the ITM, this facility provides a unique academic led service that will catalyse scientific and clinical input in an integrated structure, supporting the design and delivery of complex biological assays aimed at patient stratification and pathway validation.
The facility provides access to:
- International academic leaders and world renowned clinical experts in the areas of Rheumatology, Immunology, Gastroenterology Cancer and Metabolism.
- ITM cohorts to perform pathway discovery, target validation and patient stratification in comprehensively studied patients.
- The services of the Birmingham Human Biomaterials Resource Centre that includes human tissue processing, automated platforms for immunocytochemistry and immunofluorescence staining (VECTRA System) and last generation digital imaging analysis software (Definiens).
- Last generation flow cytometry and mass spectrometry platforms including CytoF, that will enable the processing of freshly digested human and mouse tissue (lymphoid organs, synovium, gut, liver, salivary glands etc), blood from patients and in vitro stimulated/treated cells.
- OMICS platforms including mass spectrometry, transcriptomics and metabolomics, in collaboration with experts in the relative areas of expertise.
- Comprehensively trained personnel, experts in latest generation of tools for patient stratification and functional tests with human and murine cells.